A new smart knife puts the pathology lab in the surgeon’s hands by sniffing out cancer cells as it cuts flesh. The new smart knife, also known as “iKnife,” can detect when it is cutting through cancerous tissue, raising hopes that the spread of cancer left behind after surgery could soon be curbed more successfully.
The device helps surgeons by indicating exactly which tissue to remove from a patient, reducing the need for repeated surgery. During an operation electrosurgical knives are used to cut and cauterize blood vessels. When the iKnife sucks up the smoke, it pipes the sample to a mass spectrometer capable of almost instantly analyzing the chemistry of the biological tissue to detect the presence of cancer. That translates into near-instant feedback for surgeons rather than have to wait on sample analysis by a pathology lab.
While surgery is often the best hope of a cancer cure, more than 20 per cent of the cancerous tissue may be left behind under current procedures.
“This could be a real game-changer for tumor resection surgery,” said the knife’s inventor, Dr. Zoltan Takats, from Imperial College London.
As well as potentially improving cancer survival, the device could save thousands of dollars per patient by cutting the cost of lab tests and follow-up operations. A customized version of the “iKnife” is being tested at St. Mary’s, Hammersmith and Charing Cross hospitals in London.
In an early study, the iKnife identified malignant tissue in cancer patients undergoing surgery with 100 per cent accuracy. Results of the preliminary study, involving 91 patients with cancers, are reported in the journal Science Translational Medicine. Lord Darzi, Professor of Surgery at Imperial College, said: “In cancer surgery, you want to take out as little healthy tissue as possible, but you have to ensure that you remove all of the cancer.”
A company called Medimass has been set up to develop the device commercially. Dr. Takats, one of its founders, said the team hoped to be able to secure a partnership deal with a “big industrial player” to produce and distribute the iKnife.
Modified versions of the device could have a number of non-medical applications, including food testing. “We’ve already shown that it can distinguish between horse meat and beef, and it works on cooked as well as raw meat,” Dr. Takats said.
Photo: Imperial College London